Which type V lipid-anchored protein example is characterized by N-myristoylation?

The characterization of a type V lipid-anchored protein through N-myristoylation highlights the specific covalent attachment of a myristic acid (a 14-carbon saturated fatty acid) to the amino terminus of the protein during the post-translational modification process. This myristoylation occurs via an amide bond, enabling the protein to anchor to the inner leaflet of the plasma membrane.

In the context of lipid-anchored proteins, type V proteins are distinct due to their reliance on this particular lipid modification for membrane association, which is crucial for their biological functions. N-myristoylation helps in localizing proteins to specific cellular membranes, influences protein-protein interactions, and plays a significant role in signal transduction pathways.

While integral membrane proteins and peripheral proteins also interact with membranes, they do not specifically undergo N-myristoylation as a defining modification. Integral membrane proteins typically span the membrane with hydrophobic regions, while peripheral proteins are loosely attached to the membrane surface through non-covalent interactions. Type VI lipid-anchored proteins involve different types of lipid modifications, such as palmitoylation or geranylgeranylation, rather than myristoylation.

Identifying type V lipid-anchored proteins through N