What functional group can donate a hydrogen bond in carboxylic acids?

Prepare for the UofT BCH210H1 Biochemistry I midterm with exam-like questions. Access detailed solutions and explanations for proteins, lipids, and metabolism topics. Strengthen your understanding and excel on test day!

In carboxylic acids, the functional group that can donate a hydrogen bond is the hydroxyl group. A carboxylic acid consists of a carboxyl group (-COOH), which includes both a carbonyl group (C=O) and a hydroxyl group (–OH).

The hydroxyl group possesses a hydrogen atom that is partially positive due to the electronegative oxygen atom attracting the electrons closer to itself. This configuration allows the hydrogen to participate in hydrogen bonding, making it available to interact with electronegative atoms, such as oxygen or nitrogen, in other molecules.

This capacity to donate a hydrogen bond is significant for the solubility and reactivity of carboxylic acids, affecting their overall properties in biochemical systems.

The other groups mentioned do not have the same ability to donate hydrogen atoms for hydrogen bonding in the context of carboxylic acids. The amine group's nitrogen, while capable of forming hydrogen bonds, would not be a part of the carboxylic acid structure itself. The carbonyl group can participate in hydrogen bonding as an acceptor, but it does not provide a hydrogen that can be donated. The phosphate group can also form hydrogen bonds, but like the amine group

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